Chemical Synthesis of Modularly Modified Analogs of E2/NS1 Peptides on a Novel Chemically and Mechanically Stable Terpolymer of 1,6-Hexanediol Diacrylate, N-Vinylpyrrolidone on Styrene Support

Analysis of the chemokine analogs synthesised on a terpolymer-polystyrene, N-vinylpyrrolidone, 1,6-hexanediol diacrylate crosslinked resin (PS-NVP-HDDA) showed it can be used good solid support for chemical synthesis polypeptides. The polymer with swelling character and resistance was by radical aqueous suspension polymerisation technique. HPLC analysis crude peptides PS-NVP-HDDA that is better substitute most currently available peptide synthesis. HIGHLIGHTS This article includes modularly modified E2/NS1 synthesized IIe-Phe-Thr-Tyr-His-Phe-Asn-Ser-Ser-Ser-Gly-Cys(Acm)-Pro-Glu-Ala-Asp-Leu-Asp- Cys(Acm)-Arg-Ser-Lys-Leu-Arg chemically mechanically stable terpolymer diacrylate, N-vinylpyrrolidone styrene exhibited great purity GRAPHICAL ABSTRACT